| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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| Ketoconazole Basic information | |
| Product Name: | Ketoconazole |
| Synonyms: |
,3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm; ketoisdin;kw-1414;nizoral |
| CAS: | 65277-42-1 |
| MF: | C26H28Cl2N4O4 |
| MW: | 531.43 |
| EINECS: | 265-667-4 |
| Product Categories: |
Active Pharmaceutical Ingredients;Organics;Antifungals for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry; Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals; API;API's;Antifungal;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard;KETOZOLE |
| Mol File: | 65277-42-1.mol |
| Ketoconazole Chemical Properties | |
| Melting point | 146°C |
| density | 1.4046 (rough estimate) |
| refractive index | -10.5 ° (C=0.4, CHCl3) |
| Fp | 9ºC |
| storage temp. | 2-8°C |
| solubility | metha: soluble50mg/mL |
| pka | pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain) |
| form | Off-white solid |
| color | white to light yellow |
| optical activity | [α]20/D -1 to 1°, c = 4 in metha |
| Water Solubility | Soluble in DMSO, water |
| Merck | 145302 |
| CAS DataBase Reference | 65277-42-1(CAS DataBase Reference) |
| Application | An antifungal drug for the treatment of athlete's foot and excessive dandruff |
Spec. Ketoconazole
| Items | Specification | Results |
| Appearance | White or almost white crystalline powder | confirms |
| Identification | IR | Confirms |
| Melting range, °C | 148.0~152.0 | 148.0~150. |
| Specific Rotation | -1.0o~+1.0o | 0o |
| Loss on Drying, % | ≤ 0.50 | 0.1 |
| Residue on Ignition, % | ≤ 0.10 | 0.06 |
| Heavy Metals, % | ≤ 0.002 | < 0.002 |
| Chromatographic purity, % | ≤ 2.0 | Confirms |
| Residue Solvent, % | ||
| Acetoacetate | ≤ 0.50 | 0.3 |
| Dimethyl sulfoxide | ≤ 0.50 | 0.2 |
| Bacteria | Not more than 10 per g | Confirms |
| Mold & yeast | None-detected | Confirms |
| Assay, % | 98.0~102.0 | 99.2 |
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Ketoconazole is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet.
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