| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Product Name: Prostaglandin E2
Synonyms: DINOPROSTONE;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid;(5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID;PROSTAGLANDIN;PROSTAGLANDIN E2
CAS: 363-24-6
MF: C20H32O5
MW: 352.47
EINECS: 206-656-6
Chemical Properties: White to pale yellowish-cream powder
Uses: The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient.
It is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.
As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour. It stimulates labor and delivery by stimulating the uterine, and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man.
In babies it is used in those with congenital heart defects until surgery can be carried out.
Specification:
| Items | Standards | Results | |
| Appearance | White or off-white solid powder | Complies | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Solubility | Soluble in DMF, sparingly soluble in TH, slightly soluble in methano and acetonitril, very sightly soluble in ethanol and dichloromethan, insoluble in water | Complies | |
| Polymorphic Form | Polymorphic form 1 | Complies | |
| Melting Point | 211ºC~216ºC | 212.8ºC~214.9ºC | |
| Water Content | ≤ 0.50% | 0.10% | |
| Heavy Metals | ≤ 20ppm | Complies | |
| Residue on Ignition | ≤ 0.20% | 0.09% | |
| Related Substance | Any single impurity: ≤0.10% | 0.06% | |
| Total Impurities: ≤1.00% | 0.16% | ||
| Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
| Particle Size | D90: ≤100µm | Complies | |
| Reference Standard | In-house Standard | ||
| Conclusion | The product complied to In-house standard. | ||
Related products:
| Product name | Cas No. | Product name | Cas No. |
| Latanoprost | 130209-82-4 | Carboprost tromethamine | 58551-69-2 |
| Bimatoprost | 155206-00-1 | Limaprost | 74397-12-9 |
| Travoprost | 157283-68-6 | Isopropyl Unoprostone | 120373-24-2 |
| Dinoprostone | 363-24-6 | Carboprost methylate | 62776-96-9 |
| Dinorprost tromethamine | 38562-01-5 | Gemeprost | 64318-79-2 |
| Misoprostol | 59122-46-2 | Beraprost sodium | 88475-69-8 |
| Alprostadil | 745-65-3 | Tafluprost | 209860-87-7 |
| d-Cloprostenol sodium | 62561-03-9 | Iloprost | 78919-13-8 |
| Cloprostenol sodium | 55028-72-3 | Lubiprostone | 136790-76-6 |
| (+)-Cloprostenol Sodium |
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