Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Cimetidine |
Characteristics | Almost white crystalline powder, odorless |
Identification | Infrared absorption: Should conform Ultraviolet absorption:Should conform |
Loss on drying | Not more than 0.5% |
Residual solvents | Absolute ethanol : Not more than 0.5% Ethy acetat: Not more than 0.5% |
pH value | 4.0 ~5.0 |
Residue on ignition | Not more than 0.2% |
Heavy metals | Not more than 0.002% |
Chromatographic purity | Should conform |
Assay (C10H16N6S·HCl) | 98.0%~102.0% |
Bacterial endotoxins Ph, Ch. | Not more than 0.5 eu /mg |
Item
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Standard
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Result
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Appearance
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White or off-white crystalline powder odorless, bitter taste
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Conforms
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IR Absorption
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Consist with the spectra obtained with Cimetidine CRS.
|
Conforms
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UV Absorption
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Should conform
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Conforms
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Melting point
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139-144°C
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140.5-141.0°C
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Heavy metal
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≤20ppm
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<20ppm
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Residue on ignition
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≤0.2%
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0.02%
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Related substances
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Single impurity≤0.2%
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0.15%
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Total impurity≤1.0%
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0.47%
|
|
Loss on drying
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≤1.0%
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0.06%
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Organic volatile impurities (ethanol) (loss on drying)
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≤0.5%
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0.06%
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Assay (calculated with reference on dried substance)
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98.0-102.0%
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99.60%
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1. Cimetidine is used to treat ulcers of the stomach and intestines and prevent them from coming back after they have healed.
(1) Treats stomach and intestinal ulcers;
(2) Helps prevent ulcers from forming;
(3) Treats some hypersecretory conditions;
(4) Decreases stomach acid production.
2. This medication is also used to treat certain stomach and throat (esophagus) problems caused by too much stomach acid (e.g., Zollinger-Ellison syndrome, erosive esophagitis) or a backward flow of stomach acid into the esophagus (acid reflux disease/GERD). Decreasing extra stomach acid can help relieve symptoms such as stomach pain, heartburn, difficulty swallowing, persistent cough, and trouble sleeping. It can also prevent serious acid damage to your digestive system (e.g., ulcers, cancer of the esophagus).
3. Cimetidine belongs to a class of drugs commonly called H2 blockers. It works by reducing the amount of acid in your stomach.
4. This medication is also available without a prescription. It is used to treat occasionalheartburn caused by too much acid in the stomach (also called acid indigestion or sour stomach). It is also used to prevent heartburn and acid indigestion caused by certain foods and beverages. If you are taking this medication for self-treatment, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist. (See also Precautions.)