Hot Sale Eplerenone CAS 107724-20-9

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: 10%
• Model NO.: TGY022019041903
• Product Name: Eplerenone
• Appearance: White Powder
• Test Methods: HPLC
• Shelf Life: 2 Years
• Shipping Methods: DHL, FedEx, TNT and EMS
• MOQ: 1g
• CAS No.: 200-035-3
• Storage: 2 Years
• Spe: 99%
• Transport Package: Foil Bag, Box, Drum
• Specification: 99% min
• Trademark: TGY
• Origin: China
• HS Code: 2932999099
• Production Capacity: 1000kg/Month

Product Description

 

_{Product Name: Eplerenone
Chemical Name: Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-
lactone methyl ester
Molecular Formula: C24H30O6
Molecular weight: 414.49
CAS NO.: 107724-20-9
Appearance: white crystalline powder; slightly soluble in water.
Standard: Enterprise Standard}

<sub>Eplerenone is an aldosterone antagonist used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it is much more selective for the mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, progestogen, or estrogenic effects), and is specifically marketed for reducing cardiovascular risk in patients following myocardial infarction. It was marketed by Pfizer under the trade name Inspra but is now only available as a generic in every country except the United Kingdom. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but still keep potassium.

Eplerenone is specifically indicated for the reduction of risk of cardiovascular death in people with heart failure and left ventricular dysfunction within 3-14 days of an acute myocardial infarction, in combination with standard therapies and as treatment against hypertension. It appears equivalent to spironolactone but is much more expensive.</sub>

TEST ITEMS	SPECIFICATION	RESULTS
Description	White or Almost White Crystalline Powder	white powder
Identification	A.B.	Positive
Assay	97.0~102.0%	99.3%
Specific Rotation	+101°~+105°	+102.6°
Loss On Drying	1.0%max	0.27%
Melting Point	153~157°C	153.0~155.0°C
Organic Volatile Impurities	meets the requirement.	Conforms
Related Substances	meets the requirement.	Conforms
Residual Solvents	meets the requirement.	Conforms
Particle Size	100% ≤ 20 microns	Conforms
Conclusion	The specification conform with USP30 standard

 _{Eplerenone is specifically indicated for the reduction of risk of cardiovascular death in people with heart failure and left ventricular dysfunction within 3-14 days of an acute myocardial infarction, in combination with standard therapies and as treatment against hypertension. It appears equivalent to spirono lactone but is much more expensive.
Treating high blood pressure alone or along with other medicines. It is also used to improve survival in patients who have certain heart problems (left ventricular systolic dysfunction and congestive heart failure) following a heart attack. It may also be used for other conditions as determined by your doctor.
Eplerenone is an aldosterone blocker. It works by blocking the hormone aldosterone, which lowers the amount of sodium and water the body retains. This helps to lower blood pressure to help prevent strokes, heart attacks, and kidney problems.}