| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Product name:alectinib
CAS:1256580-46-7
Molecular Formula:C30H34N4O2
Molecular Weight:483
EINECS No:821-541-6
Specification:99%
Alectinib (CH5424802) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.
Alectinib intermediate should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Specification:
|
Item |
Specification |
|
Appearance |
White Crystalline Powder |
|
Assay (HPLC) |
99% |
|
Identification |
Infrared Absorption |
|
Loss On Drying |
≤0.2% |
|
Residue On Ignition |
≤0.3% |
|
Chloride |
≤0.05% |
|
Sulfate |
≤0.03% |
|
Heavy Metals |
≤0.0015% |
Alectinib (CH5424802) is an ATP-competitive inhibitor for ALK and L1196M with Ki values of 0.83 nM and 1.56 nM, respectively. CH5424802 prevents autophosphorylation of ALK, and also suppresses the phosphorylation of STAT3 and AKT, but not of ERK1/2. CH5424802 elicits an apoptotic marker-caspase-3/7-like activation-in NCI-H2228 spheroid cells. CH5424802 blocks the growth of two NPM-ALK expressing lymphoma lines, KARPAS-299 and SR with greater efficacy against KARPAS-299 at an IC50 of 3 nM.
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