| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP |
| Suitable for: | Animals |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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| Product Name | Diclofenac sodium |
| CAS | 15307-79-6 |
| MF | C14H10Cl2NNaO2 |
| MW | 318.13 |
| EINECS | 239-346-4 |
| Mol File | 15307-79-6.mol |
Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite
4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.
Diclofenac sodium Specification:
| Items | Specifications | Results |
| Appearance | Pure white crystalline powder, slightly hygroscopic. | Conforms |
| Solubility | Sparingly soluble in water, ethanol(96%);slightly soluble in ; practically insoluble in ether. | Conforms |
| Identify | (A) IR-Spectrum (B) Reaction of sodium salt | Conforms/ Positive |
| Acidity or alkalinity | 7.0-8.5 | 7.50% |
| Appearance of solution | Clear;Absorption of sodium salt≤0.05 | Conforms |
| Single impurity | max 0.2% | Conforms |
| total impurity | max 0.5% | Conforms |
| Heavy metal | Max 10ppm | Conforms |
| Loss on drying | Max 0.5% | 0.22% |
| Assay | 99.0-101.0% | 99.60% |
| Conculsion | The results can conform to BP2010 Standard |
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1. It is used to relieve the swelling and pain symptoms of rheumatoid arthritis, osteoarthritis, spinal arthropathy, gout arthritis, rheumatoid arthritis and other arthritis.
2. It is used to treat rheumatic pain of all kinds of non-articular soft tissues, such as shoulder pain, tenosynovitis, bursitis, muscle pain and post-exercise injury pain, etc.;
3. Used for acute mild and moderate pain, such as after surgery, after trauma, after labor injury, dysmenorrhea, toothache, headache, etc.; It has certain antipyretic effect on heat.
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