High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6

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Customization: Available
Powder: Yes
Customized: Customized
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  • High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
  • High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
  • High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
  • High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
  • High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
  • High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
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Basic Info.

Model NO.
TGY022019042604
Certification
GMP, HSE, ISO 9001, USP, BP
Suitable for
Elderly, Adult
State
Solid
Purity
>99%
Product Name
Olopatadine Hydrochloride
Appearance
White Powder
Specificcation
99%
CAS No.
140462-76-6
Grade
Pharmaceuticals Grade
Shelf Life
2 Years
Storage
Cool Dry Place
Shipping Time
Within 3-7 Working Days
Transport Package
Foil Bag, Box, Drum
Specification
99% min
Trademark
TGY
Origin
China
HS Code
4802209000
Production Capacity
1000kg/Month

Product Description


High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6
High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6

Product Name: Olopatadine hydrochloride;
Synonyms: OLOPATADINE HCL;OLOPATADINE HYDROCHLORIDE;OLOPATDINEHYDROCHLORIDE;OLOPATADINE HYDROCHLORIDE AND THE INTERMEDIATES;(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride;OLAPATADINE HCL;Olopatadine Hydrochloride (150 mg);Olopatadin HCL;
CAS: 140462-76-6;
MF: C21H24ClNO3;
MW: 373.87;
Product Categories: Pharmaceutical material and intermeidates;APIs;Olopatadine;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Opatanol, Pataday, Patanase, Allelock;API;
Melting point: 242-245 ºC;
storage temp.: Refrigerator;
Purity:99%
Apperance:white powderOlopatadine hydrochloride is an antihistamine (as well as anticholinergic and mast cell stabilizer), sold as a prescription eye drop manufactured by Alcon in one of three strengths: 0.7% solution or Pazeo in the US, 0.2% solution or Pataday (also called Patanol S in some countries), and 0.1% or Patanol (also called Opatanol in some countries). It is used to treat itching associated with allergic conjunctivitis (eye allergies). A decongestant nasal spray formulation is sold as Patanase, which was approved by the FDA on April 15, 2008. It is also available as an oral tablet;

It should not be used to treat irritation caused by contact lenses. The usual dose for Patanol is 1 drop in each affected eye 2 times per day, with 6 to 8 hours between doses. Both Pazeo and Pataday are dosed 1 drop in each eye daily.

There is potential for Olopatadine as a treatment modality for steroid rebound (red skin syndrome).


High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6

Olopatadine is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.

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High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6

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High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6

High Purity 99% Olopatadine Hydrochloride CAS 140462-76-6

 

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