Pharmaceutical Material Phenolphthalein Powder CAS 77-09-8 API Phenolphthalein

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Powder
• Purity: >98%
• Model NO.: TGY201904250705
• Appearance: White or off-White Powder
• Molecular Formula: C20h14o4
• MW: 167.21
• Certificate: ISO 9001, USP
• Shelf Life: 24 Months
• Storage: Cool Dry Area
• Grade: Pharmaceutical Grade
• CAS No.: 77-09-8
• Sample: Avaliable
• Service: OEM
• MOQ: 20g
• Assay: 98%Min, 99% HPLC
• Test Method: UV/HPLC
• Einecs No.: 201-004-7
• Active Ingredient: Phenolphthalein
• Transport Package: Boil Bag
• Specification: HPLC 99%
• Trademark: TGY
• Origin: Xi′an, Shaanxi, China (Mainland)
• HS Code: 29339900
• Production Capacity: 3000kg/Month

Product Description

 

Brand	TGY
Product Name	Phenolphthalein
CAS No.	77-09-8
EINECS	201-004-7
Molecular Formula	C20H14O4
Molecular Weight	318.32276
Appearance	White to light yelow powder
Purity	99%

COA of Phenolphthalein
 

TEST ITEM	SPECIFICATION	RESULTS
Characteristics	A white or almost white powder, practically insoluble in water, soluble in alcohol.	A white powder, practically insoluble in water, soluble in alcohol.
Melting Point	It melts at about 260°C.	261ºC.~262ºC.
Identification	A: Positive B: Positive	A: Positive B: Positive
Appearance of solution	The solution is clear and not more intensely colored than reference solution Y7	Complies
Related substances	Less than 0.5%	<0.5%
Heavy metals	Not more than0.001%	<0.001%
Acidity or alkalinity	Complies	Complies
Chlorides	Not more than 0.01%	<0.01%
Sulfates	Not more than 0.02%	<0.02%
Loss on drying	Not more than 0.5%	0.12%
Sulfated ash	Not more than 0.1%	0.01%
Assay	98.0%-101.0%(C20H14O4)	99.6%
CONCLUSION: Conform With  EP6/BP2009

Classification
Digestive system drugs> Promote diarrhea drugs

Pharmacological effects
Phenolphthalein irritating laxatives, the main role in the large intestine. After oral administration in the intestinal alkaline environment to form soluble sodium salt, stimulate the plexus wall plexus, a direct role in the intestinal smooth muscle, so that peristalsis increased.
At the same time phenolphthalein and inhibit intestinal absorption of water, so that water and electrolyte accumulation in the colon,
resulting in laxation effect. The role of strength and intestinal size of alkaline, and its role in mild, rarely cause intestinal spasm.

Pharmacokinetics
Phenolphthalein after oral 6 ~ 8h effect. About 15% of oral absorption after absorption of drugs mainly in the form of glucuronide by the kidneys or excretion of excreted, some can also be excreted to the intestine by the bile, was reabsorbed in the intestine to form enterohepatic circulation, thereby prolonging the duration of action, So the role of a single administration of sustainable 3 to 4 days. The unabsorbed part is excreted via feces. Phenolphthalein can also be secreted by milk.

Indications
1 for habitual intractable constipation.
2. In the colon, rectal endoscopy or X-ray examination for cleaning the intestine.

Contraindications
1. Allergic to phenolphthalein.
2. Baby
3. Appendicitis
4. Rectal bleeding is not diagnosed.
5. Congestive heart failure.
6. Hypertension.
7. Intestinal obstruction.
8. Renal insufficiency.
9. fecal blockage.

Precautions
1. Young children and pregnant women with caution.
2. Should be taken before going to bed, to avoid abuse of phenolphthalein.

Adverse reactions
Phenolphthalein is a widely accepted laxative that is readily accepted by patients. Occasionally intestinal cramps, bleeding tendency,
a rare allergic reaction. Overdose or long-term drug disorders, induced arrhythmia, confusion, muscle spasms, and fatigue, and other symptoms.

Dosage
Each 50 ~ 200mg, Dayton clothing before going to bed. Bedridden each time 200mg. The amount of each 500mg, 1g daily. Increase
or decrease according to the patient's condition.

Medicine interactions
Phenolphthalein and sodium bicarbonate, magnesium oxide, and other alkaline drugs can cause discoloration of urine.

Poisoning
Phenolphthalein (Fenofutin; fruit guide for the drug-containing tablets) as a laxative agent, due to the small amount of absorption after the results of enterohepatic circulation, the role of sustainable 3 ~ 4d. Commonly used before going to bed 0.05 ~ 0.2g. When poisoning mainly
damage the liver and kidneys.

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