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Pramoxine hydrochloride Quick Details
Other name Pramoxine , Pramoxine HCL ,Proctofoam , Tronothane Hydrochloride
MF:C17H28ClNO3
MW:329.86
CAS:637-58-1
EINECS :211-293-1
Purity:99%
Quality Standards Enterprise Standard/Pharma Grade
Visual Appearance: White to Off-White Crystalline Solid
Application
1)muscle relaxant (smooth)
2)slows growth of unwanted facial hair
Pramocaine (INN and BAN, also called pramoxine or pramoxine HCI) is really a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramoxine hydrochloride stood out among a few alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent
Pharmacologic study revealed that it is potent and also low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine cuts down on permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, resulting in numbness.
Topical anesthetics are utilized to relieve pain and irritation caused by conditions like sunburn or any other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine can also be common ingredients in over the counter hemorrhoid preparations.
Anesthesia, local- Proparacaine and tetracaine are indicated to create local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removing foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy.
Proparacaine hydrochloride and tetracaine may also be indicated to generate local anesthesia prior to surgical procedures for example cataract extraction and pterygium excision, usually just as one adjunct to locally injected anesthetics.
Ophthalmic solutions employed for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium in case a significant volume of solutionenters the eye with the incision..