99% Pharmaceutical Digestive Antiemetic Domperidone Powder CAS 57808-66-9

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: TGY022019051302
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Product Name: Domperidone Powder
• Specificcation: 99%
• Grade: Pharmaceuticals Grade
• Shelf Life: 2 Years
• Storage: Cool Dry Place
• Shipping Time: Within 3-7 Working Days
• CAS: 57808-66-9
• Appearance: White Powder
• Transport Package: Foil Bag, Box, Drum
• Specification: 99% min
• Trademark: TGY
• Origin: China
• HS Code: 300440906
• Production Capacity: 1500kg/Month

Product Description

Domperidone
CAS No.:	57808-66-9
Synonyms:	6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;
Formula:	C22H24ClN5O2
Exact Mass:	425.16200
Molecular Weight:	425.91100
PSA:	78.82000
LogP:	3.29110
Appearance	white powder
Density:	1.341 g/cm3
Melting Point:	242.5ºC
Stability:	Stable. Incompatible with strong oxidizing agents.
Storage Condition:	Keep tightly closed.

• _{A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.}
• _{Domperidone is a commonly used antiemetic and gastro-kinetic drug with its appearance being white to light yellow powder and bitter taste. It is almost insoluble in water, slightly soluble in ethanol, easily soluble in lactic acid as well as soluble in citrate. This product is a kind of peripheral dopamine receptor antagonists with strong action.}
• _{Domperidone can block the DA1 and DA2 receptor next to the synapses, antagonizing the inhibitory effect of dopamine on the postsynaptic cholinergic neurons of myenteric plexus and causing the stomach contractions. It can promote the motility and tension of digestive tract motility to return to normal function, promoting the emptying of stomach, increasing the motility of gastric antral and duodenum, coordinating the contraction of the pylorus as well as enhancing the esophageal peristalsis and the tension of the lower esophageal sphincter.\}

<sub>1. Gastrointestinal problems
There is some evidence that domperidone has antiemetic activity. Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting.
It can be used in patients with Parkinson's disease because, unlike metoclopramide, domperidone does not cross the blood-brain barrier.
Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated "for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis." The drug may also be used "to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents".
2. Lactation
The hormone prolactin stimulates lactation in humans, and its release is inhibited by the dopamine secreted by the hypothalamus. Domperidone, by acting as an anti-dopaminergic, results in increased prolactin secretion, and thus promotes lactation

COA of Domperidone Powder  :</sub>

Items	Requirements	Results
Appearance	White to off white powder	White powder
Solubility	Practically insoluble in water, soluble in dimethylformamide,  slightly soluble in ethanol(96%) and in meth	Confirms
Identification	A. M.P. 244~248ºC	244.5~245.5ºC
	B. IR should comply	Confirms
	C. TLC should comply	Confirms
	D. It gives the reaction of non-nitrogen substituted barbiturates.	Confirms
Clarity of solution	The solution is clear and not more intensely colored than  reference solution Y6	Confirms
Related substance	Total impurities≤0.5%	≤0.29%
	Individual impurity≤0.25%	≤0.18%
Loss on drying	≤0.5%	0.07%
Sulphated ash	≤0.1%	≤0.05%
Heavy metal	≤20ppm	<20ppm
Assay	99.0%~101.0%	99.49%