| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Vitamin B12 commonly used specifications are Cyanocobalamin, Methylcobalamin, Cobamamide((Adenosylcobalamin) and Hydroxocobalamin (Hydroxocobalamin HCL and Hydroxocobalamin Acetate) in foods, nutrients, and feed.
Cyanocobalamin is usually prescribed after surgical removal of part or all of the stomach or intestine to ensure adequate serum levels of vitamin B12.It is also used to treat pernicious anemia, vitamin B12 deficiency (due to low intake from food or inability to absorb due to genetic or other factors), thyrotoxicosis, hemorrhage, malignancy, liver disease and kidney disease. Cyanocobalamin injections are often prescribed to gastric bypass patients who have had part of their small intestine bypassed, making it difficult for B12 to be acquired via food or vitamins.
Cyanocobalamin is also used to perform the Schilling test to check ability to absorb vitamin B 12.
Cyanocobalamin is also produced in the body (and then excreted via urine) after intravenous hydroxycobalamin is used to treat cyanide poisoning.
Historically, the physiological form was initially thought to be cyanocobalamin. This was because hydroxocobalamin produced by bacteria was changed to cyanocobalamin during purification in activated charcoal columns after separation from the bacterial cultures (because cyanide is naturally present in activated charcoal).Cyanocobalamin is the form in most pharmaceutical preparations because adding cyanide stabilizes the molecule.
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. This vitamer is one of two active coenzymes used by vitamin B12-dependent enzymes and is the specific vitamin B12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase.
Methylcobalamin is produced by some bacteria. It plays an important role in the environment. In the environment, it is responsible for the biomethylation of certain heavy metals. For example, the highly toxic methylmercury is produced by the action of methylcobalamin.In this role, methylcobalamin serves as a source of "CH3+".
A lack of cobalamin can lead to megaloblastic anemia and subacute combined degeneration of the spinal cord.
Adenosylcobalamin, also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin, one of the biologically active forms of vitamin B12.
Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosyl radical through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with a bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme active site. An enzyme that uses adenosylcobalamin as a cofactor is methylmalonyl-CoA mutase (MCM).
Hydroxocobalamin is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat vitamin B12 deficiency including pernicious anemia. Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.It is given by injection into a muscle or vein.
Specification:
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Items |
Specification |
Test method |
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Characteristics |
Dark red crystals or amorphous or crystalline red powder |
Visual method |
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Identification A |
UV: The absorption spectrum exhibits maxima at 278±1nm,361±1nm,and550±2nm. |
USP monograph |
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A361/A278nm:1.70-1.90 A361/A550nm:3.15-3.4 |
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Identification B |
Cobalt:Meets USP requirements |
USP monograph |
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Identification C |
HPLC: The retention time of the major peak of the sample solution corresponds to that of the atandard solution. |
USP monograph |
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Loss on drying |
≤10.0% |
USP monograph/USP<731> |
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Assay |
97.0%-102.0% |
USP monograph |
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Related substances |
Total impurities ≤3.0% |
USP monograph |
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7β,8β-Lactocyanocobalamin≤1.0% |
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34- Methylcyanocobalamin≤2.0% |
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8-Epi-cyanocobalamin≤1.0% |
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Any other unidentified impurity and 50-Carboxycyanocobalamin,32- Carboxycyanocobalamin≤0.5% |
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Total aerobic microbial |
≤1000cfu/g |
ChP<1105> |
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Yeast & mould |
≤100cfu/g |
ChP<1105> |
1) Vitamin B12 can resistance to fatty liver, promote storage of vitamin A in liver
2) Vitamin B12 Promote cell mature and body metabolism.
3) Vitamin B12 participates in the manufacturing of bone marrow RBC , so it can be the treatment of pernicious anemia.
4) Vitamin B12 increases folic acid utilization rate, promote carbohydrate, fat and protein metabolism
5) Vitamin B12 can promote methyl transferase
6) Vitamin B12 Promote the development and maturation of red blood cells, so that the body hematopoietic function in a normal state, the prevention of pernicious anemia; maintain a healthy nervous system
7) Vitamin B12 has the function of activate amino acids and promote the biosynthesis of nucleic acids, can promote protein synthesis,it plays an important role for growth and development of infants and young children
8) Vitamin B12 can metabolize fatty acids and make fat, carbohydrates, protein can be properly used by body.
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