| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, ISO 9001, USP, BP |
| Suitable for: | Elderly, Adult |
| State: | Powder |
| Purity: | >98% |
| Samples: |
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| Customization: |
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Basic information CAS NO.34552-83-5 Loperamide hydrochloride:
| Product Name | Loperamide hydrochloride |
| Synonyms | 4-(4-(p-chlorophenyl)-4-hydroxy-1-piperidyl)-n,n-dimethyl-2,2-diphenylbutyra;4-(p-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-diphenyl-1-piperidine;blox;butyramidehcl;dissenten;fortasec;imodium;imosec |
| CAS | 34552-83-5 |
| MF | C29H34Cl2N2O2 |
| MW | 513.5 |
| EINECS | 252-082-4 |
| Product Categories | ACTIVE PHARMACEUTICAL INGREDIENTS;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Opioid receptor and opioid-like receptor;Amines;Heterocycles;IMODIUM;Other APIs |
Chemical Properties CAS NO.34552-83-5 Loperamide hydrochloride:
| Melting point | 223-225°C |
| refractive index | 1.6100 (estimate) |
| density | 1.1905 (rough estimate) |
| pka | 8.66(at 25ºC) |
| storage temp. | Store at RT |
| Merck | 14,5571 |
Spec. CAS NO.34552-83-5 Loperamide hydrochloride:
|
Test |
Specification | Result |
| Appearance | White to off white crystalline powder with a characteristic sulfide-like order | Complies |
| Assay,(Anhydrous)% | 98.0% to 101.5% | 100.2% |
| Loss on drying % | ≤0.5% | 0.06% |
| Identification | IR:similar to Reference Standard | Complies |
| Specific Rotation | -127°to -132° | -131° |
| Sulphated Ash | ≤0.2% | 0.03% |
| Heavy metals | ≤0.002% | Complies |
| pH | 2.0 to 2.6 | 2.3 |
| Related Compouds |
1.Single Impurity ≤1.0% 2.Sum of Impurity≤2.0% |
Undetected Undetected |
Loperamide hydrochloride is a white or almost white crystalline powder, can be used as antidiarrheal, or long-acting anti-diarrheal drug, used for treating acute and chronic dysentery. When overdose may occur drowsiness, constipation, muscle tension, restlessness, bradycardia and other respiratory symptoms, naloxone detoxification available, and patients were observed for at least 48 hours in order to detect inhibition of the central nervous system.
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Antidiarrheal drugs. Various causes for the symptoms of acute and chronic diarrhea. Ileum for ostomy patients can reduce the volume and frequency of defecation, stool thick to increase hardness.
1. patients with diarrhea, especially children, frequent loss of water and electrolytes, replenish water and electrolytes is the most important therapeutic measures, children should the FDA under the guidance of a doctor.
2. for acute diarrhea, such as 48 hours after using this service, no improvement in clinical symptoms, should stop using, it is recommended to consult a doctor.
3. liver dysfunction may lead to drug overdose relative, should pay attention to the central nervous system symptoms of toxic reactions.
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