Powder: | Yes |
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Customized: | Customized |
Certification: | GMP, ISO 9001, USP, BP |
Suitable for: | Elderly, Adult |
State: | Powder |
Purity: | >98% |
Samples: |
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Customization: |
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Brand | TGY |
Product Name |
Phenolphthalein |
CAS No. |
77-09-8 |
EINECS |
201-004-7 |
Molecular Formula |
C20H14O4 |
Molecular Weight |
318.32276 |
Appearance |
White to light yelow powder |
Purity |
99% |
COA of Phenolphthalein
TEST ITEM |
SPECIFICATION |
RESULTS |
Characteristics |
A white or almost white powder, practically insoluble in water, soluble in alcohol. |
A white powder, practically insoluble in water, soluble in alcohol. |
Melting Point |
It melts at about 260°C. |
261ºC.~262ºC. |
Identification |
A: Positive B: Positive |
A: Positive B: Positive |
Appearance of solution |
The solution is clear and not more intensely colored than reference solution Y7 |
Complies |
Related substances |
Less than 0.5% |
<0.5% |
Heavy metals |
Not more than0.001% |
<0.001% |
Acidity or alkalinity |
Complies |
Complies |
Chlorides |
Not more than 0.01% |
<0.01% |
Sulfates |
Not more than 0.02% |
<0.02% |
Loss on drying |
Not more than 0.5% |
0.12% |
Sulfated ash |
Not more than 0.1% |
0.01% |
Assay |
98.0%-101.0%(C20H14O4) |
99.6% |
CONCLUSION: Conform With EP6/BP2009 |
Classification
Digestive system drugs> Promote diarrhea drugs
Pharmacological effects
Phenolphthalein irritating laxatives, the main role in the large intestine. After oral administration in the intestinal alkaline environment to form soluble sodium salt, stimulate the plexus wall plexus, a direct role in the intestinal smooth muscle, so that peristalsis increased.
At the same time phenolphthalein and inhibit intestinal absorption of water, so that water and electrolyte accumulation in the colon,
resulting in laxation effect. The role of strength and intestinal size of alkaline, and its role in mild, rarely cause intestinal spasm.
Pharmacokinetics
Phenolphthalein after oral 6 ~ 8h effect. About 15% of oral absorption after absorption of drugs mainly in the form of glucuronide by the kidneys or excretion of excreted, some can also be excreted to the intestine by the bile, was reabsorbed in the intestine to form enterohepatic circulation, thereby prolonging the duration of action, So the role of a single administration of sustainable 3 to 4 days. The unabsorbed part is excreted via feces. Phenolphthalein can also be secreted by milk.
Indications
1 for habitual intractable constipation.
2. In the colon, rectal endoscopy or X-ray examination for cleaning the intestine.
Contraindications
1. Allergic to phenolphthalein.
2. Baby
3. Appendicitis
4. Rectal bleeding is not diagnosed.
5. Congestive heart failure.
6. Hypertension.
7. Intestinal obstruction.
8. Renal insufficiency.
9. fecal blockage.
Precautions
1. Young children and pregnant women with caution.
2. Should be taken before going to bed, to avoid abuse of phenolphthalein.
Adverse reactions
Phenolphthalein is a widely accepted laxative that is readily accepted by patients. Occasionally intestinal cramps, bleeding tendency,
a rare allergic reaction. Overdose or long-term drug disorders, induced arrhythmia, confusion, muscle spasms, and fatigue, and other symptoms.
Dosage
Each 50 ~ 200mg, Dayton clothing before going to bed. Bedridden each time 200mg. The amount of each 500mg, 1g daily. Increase
or decrease according to the patient's condition.
Medicine interactions
Phenolphthalein and sodium bicarbonate, magnesium oxide, and other alkaline drugs can cause discoloration of urine.
Poisoning
Phenolphthalein (Fenofutin; fruit guide for the drug-containing tablets) as a laxative agent, due to the small amount of absorption after the results of enterohepatic circulation, the role of sustainable 3 ~ 4d. Commonly used before going to bed 0.05 ~ 0.2g. When poisoning mainly
damage the liver and kidneys.
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